Generally speaking, Angong Niuhuang Wan is not effective for late-onset encephalopathy because it mainly treats acute illnesses such as high fever and coma, while late-onset encephalopathy does not have such symptoms. Angong Niuhuang Pill is a Chinese medicine for emergency treatment, which is composed of Huanglian, Scutellaria baicalensis, gardenia, tulip, icicle, oxalis, musk and so on, with the nature of the medicine being cold, and it is mainly used for the treatment of fever into the pericardium (the evil of heat encroaching on the pericardium), which leads to high fever, stupor, talking nonsense, and the so-called Yang Closure, with teeth closed, the limbs straightened and the respiratory air thick and so on. Generally speaking, Angong Niuhuang Wan can be used for the treatment of conditions such as stroke, craniocerebral trauma, encephalitis, and various infectious diseases resulting in high fever, coma and other manifestations of the disease. And delayed encephalopathy, mostly seen in carbon monoxide poisoning, is a delayed injury that occurs in the central nervous system, which is usually manifested by abnormalities in movement, sensation and emotion. There are dizziness, headache, tinnitus, memory loss, obsessive-compulsive, depression, anxiety, claustrophobia, etc., usually without high fever, coma symptoms. An Gong Niu Huang Wan should always be taken under the guidance of a traditional Chinese medicine practitioner, and if delayed encephalopathy occurs, it is important to seek medical attention in a timely manner and follow the doctor’s instructions for examination and treatment.