The importance of thyroid disease screening

  A few days ago, the news about Jinan’s abandoned baby safety island was in the news, the major media vied for coverage, and civil opinion has been debated since. Since its official opening on June 1, 2014, the Jinan abandoned baby safety island has received more than a hundred abandoned babies and even abandoned children in just a dozen days, reaching the preset acceptance limit of the Jinan Children’s Welfare Institute. The surge in the number of abandoned babies is not the original intention of the safety island, but is the result of the welfare institutions must face.  The existence of the abandoned baby safety island was controversial at the beginning of its establishment. The proponents of the abandoned baby safety island believe that the establishment of the abandoned baby island has improved the survival rate of abandoned babies and safeguarded the lives of abandoned babies, reflecting social progress; the skeptics believe that the establishment of the abandoned baby island is a disguised connivance and encouragement of abandonment, inconsistent with the law prohibiting the abandonment of babies.  For the abandoned baby island should exist in the ethical and jurisprudential debate, I believe that the civil affairs department has enough consideration, the public opinion will also be determined, I will not say more here, but in the overwhelming news reports about the safety island, caused the author’s special attention is that the Jinan abandoned baby safety island accepted more than a hundred abandoned babies, most of them have defects, and more than half of them are cerebral palsy children! It is conceivable that even if these abandoned babies survive in the “safe island”, they will be a burden to society when they grow up, and they will not be able to talk about their own happiness. Therefore, it is important to control the birth defects of babies to a minimum, which is the fundamental solution to reduce the number of abandoned babies, thus highlighting the importance of prenatal screening.  Common prenatal factors of neonatal cerebral palsy include the influence of parents’ bad habits such as smoking and drinking, or diseases such as diabetes, hypertension syndrome, hypothyroidism and excessive use of birth control pills are the causes of prenatal cerebral palsy. With the popularization of pregnancy-related knowledge and the development of periodic medical checkups in enterprises and institutions, people have a basic, at least perceptual, understanding of most of the above factors, except for thyroid-related diseases, which have not received due attention for a long time because of their similarity to normal physiological changes in the body during pregnancy.  In the last decade or so, the incidence of thyroid-related diseases in China has increased significantly, which is estimated to be related to the accelerated pace of life, increased work stress and excessive iodine intake in some areas. According to the Epidemiological Survey of Thyroid Diseases in the Community published by the China Health Education Center, in 2009, the prevalence of hyperthyroidism in China was 1.3%, hypothyroidism was 6.5%, and thyroid nodules was 18.6%. Among them, 5-15% of thyroid nodules are thyroid cancer. It is conservatively estimated that there are more than 200 million patients with thyroid disease in China, but the awareness rate of thyroid disease is very low and the overall standardized treatment rate is less than 5%. Within this context, the high prevalence of hypothyroidism in pregnancy and the low diagnosis and treatment rates in China seem to be particularly evident: the prevalence of clinical hypothyroidism in the first half of pregnancy is 0.6%, the prevalence of subclinical hypothyroidism is 5.3%, and the prevalence of hypo-T4emia is 2.2%. If these diseases are not treated and controlled in time, they will undoubtedly have a negative impact on maternal and fetal health, especially on fetal mental development.  Hypothyroidism in pregnancy is a condition in which the thyroid gland does not produce enough thyroxine to meet the body’s needs during pregnancy. Common symptoms include loss of energy, lethargy, weight gain, fear of cold, constipation and memory loss. Subclinical or mild hypothyroidism has no or only mild clinical symptoms and can easily be confused with pregnancy reactions and is not easily diagnosed.  However, hypothyroidism during pregnancy happens to be one of the major culprits of abnormal neonatal mental development and neonatal cerebral palsy: thyroid hormone has the function of promoting growth and development, and it mainly promotes the growth and development of bones, brain and reproductive organs. During the first 12 weeks of pregnancy, the fetal brain is in its first rapid development period, but the fetus’ own thyroid function has not yet been established, and the thyroid hormones needed for fetal brain development are completely dependent on the mother’s supply. If the mother-to-be suffers from hypothyroidism during this period, i.e. the mother’s thyroid hormone level continues to be low and cannot provide sufficient thyroid hormone for the fetal brain development, it will affect the fetal brain development and even cause irreversible damage, which may lead to neonatal mental retardation in mild cases or cerebral palsy in severe cases.  Although hypothyroidism in pregnancy is very dangerous, it is not difficult to avoid, in fact, as long as early screening and early treatment, it will hardly affect the development of the fetus and maternal health. For example, the commonly used medication for hypothyroidism treatment, Umethazine (levothyroxine sodium tablets), is classified by the FDA as a Class A drug, which means that it is as safe as vitamin drugs, that is, as long as it is not taken in excessive amounts, it is only a reasonable exogenous supplement to the normal hormone requirements of the human body, and therefore will not have adverse effects on pregnancy and breastfeeding.  In view of the danger of thyroid-related diseases during pregnancy and the insidiousness of symptoms, and not included in the standard pregnancy test, I would like to remind the majority of couples planning to get pregnant, do not forget to perform thyroid function and ultrasound examination before delivery, do not be negligent or avoid the idea of medical treatment, turning the joy of family into a human tragedy!