Boys go to bed after 11 o’clock will make endocrine disruption, causing obesity, fatigue and sub-healthy state. Specifically, staying up late for a long time will cause endocrine metabolism disorders, so that weight gain. Lack of sleep can also lead to mental exhaustion, easy to trigger anxiety and depression. Long-term staying up late can cause irreversible damage to brain cells, leading to memory loss and increased risk of Alzheimer’s disease with age. Long-term staying up late will also make the immune system decline, easy to feel fatigue. Men staying up late for a long time can lead to male baldness, oligospermia, hypospermia, and sexual dysfunction. In addition, staying up late for a long time can affect the vitality and quantity of male sperm. Staying up late is not only harmful to the human body as mentioned above, both men and women should try their best to rationalize their sleeping time and avoid staying up late.