Ulcers at the end of the ileum may be caused by Crohn’s disease, intestinal tuberculosis, ileal tumor, etc. They can be treated with oral medication, surgery or radiotherapy. 1. Crohn’s disease: Crohn’s disease patients due to immunity, inflammation and other reasons can cause ulcerative changes in the end of the ileum, you can use 5-aminosalicylic acid, prednisone, budesonide, azathioprine and other drugs to treat the severity of the disease with different choice of drugs, the specific use of what kind of drugs should be based on the medical practitioner to implement. 2. Intestinal tuberculosis: chronic specific infection at the end of the ileum caused by tuberculosis bacillus, causing ulcers at the end of the ileum, mainly need to take anti-tuberculosis drugs such as isoniazid, rifampicin, and so on, and if the symptom is serious, it is feasible to perform intestinal resection and anastomosis. 3. Ileal tumor: malignant tumor at the end of ileum can form malignant ulcer in the local area, which should be treated with timely surgical resection, and at the same time, radiotherapy, chemotherapy (e.g., 5-FU, vincristine, etc.) and other comprehensive treatment measures should be given. Patients with ulcers at the end of the ileum should go to the hospital in a timely manner, improve the examination, give targeted treatment after the cause is clear, not blindly use their own medicine.