Jaundice in 11 days of newborns, bilirubin 305.4umol/L suggests pathological jaundice, which needs treatment, including light therapy, medication, blood exchange therapy and so on. 1. Phototherapy: it is a simple and effective method to reduce serum bilirubin, the adverse effects include fever, diarrhea, skin rash, etc., but most of them are not serious. When the total serum bilirubin is less than 222~239umol/L, phototherapy can be stopped. 2. Drug therapy: such as giving albumin as prescribed by the doctor to reduce the occurrence of bilirubin encephalopathy. 3. Blood exchange therapy: when the total bilirubin is more than 342umol/L or the light therapy is ineffective, blood exchange therapy can be used. When the newborn is jaundiced, the type of jaundice should be clarified. If the jaundice is pathologic, it should go to the hospital in time and be treated under the doctor’s guidance.