HPV is the human papillomavirus, and HPV31 belongs to the high-risk subtype of HPV virus, which has the risk of cancer.The difficulty of HPV31 conversion is mainly related to the characteristics of the virus and the patient’s own immunity, etc. HPV infection mainly causes warts, such as common warts, flat warts and condyloma acuminatum. HPV infection mainly causes warts, such as common warts, flat warts, condyloma acuminatum, etc. HPV infects the basal cells through small trauma, and the viral genome maintains a low-copy expression in the basal cells for a long period of time, so once infected with HPV, even if the wart disappears, the infection is still persistent, and the rate of conversion is very low. For patients with strong autoimmunity, a clinical cure can be achieved if they maintain good living habits, strengthen exercise, and at the same time do the co-treatment of sexual partners and so on. However, if the virus causes cancer, it will lead to increased difficulty in treatment, and patients with precancerous lesions or even cervical cancer need to undergo surgical treatment. HPV31 positive patients need to undergo regular follow-ups and observations, and use anti-HPV medication under the guidance of a doctor. Infected patients need to look at the disease objectively and treat it actively. Those who have not been completely cleared are advised to undergo regular review.