Lack of sleep may cause puffy eyes, but other factors should be ruled out. In the case of sleep deprivation, the patient’s excessive fatigue may affect the blood circulation in the subcutaneous tissues of the eyelids, resulting in venous blood stagnation, which may cause eye swelling, and may be accompanied by the appearance of dark circles, eye soreness and other uncomfortable symptoms. Patients should go to the ophthalmology department of the hospital in a timely manner to determine if the swelling is due to fatigue, poor rest, etc., because eye infections, allergies, or kidney or heart diseases can also cause swelling of the eyelids. It is recommended that patients with significant eyelid swelling seek medical attention to evaluate their condition and follow the doctor’s instructions for treatment.