The best time to take zinc supplements is recommended in between meals. If in the morning, after breakfast and before lunch, that is, between 9:00-11:00 am. In the afternoon, after lunch and before dinner, usually between 15:00 and 17:00, the gastrointestinal tract is basically in a state of emptying, so taking trace elements will achieve the best oral bioavailability and optimal absorption and digestion by the body. However, there is one exception to this rule: patients with gastrointestinal disorders or those with previous gastric or duodenal ulcers, upper gastrointestinal bleeding, or gastroesophageal fundic varices are not suitable for zinc supplementation during this fasting period. Zinc supplements should be taken half an hour after lunch or half an hour after dinner to maximize the bioavailability of zinc ions without damaging the gastrointestinal mucosa.