In general, bone marrow transplantation preconditioning with high-dose cyclophosphamide chemotherapy does not directly cause vomiting of blood, but when a large amount of blood is vomited during the period should be considered to be caused by a primary disease, is a great danger, and must be immediately informed to the doctor in order to avoid serious consequences.
Prior to bone marrow transplantation, patients are required to undergo a course of high-dose chemotherapy, sometimes coupled with high-dose radiation therapy, a process known as preconditioning. As a result of this high-dose chemotherapy and radiotherapy during the preconditioning period, there are often a number of toxic side effects and related complications on the patient’s body.
Among them, nausea and vomiting are the most common side effects, as well as oral pain, diarrhea, neurological symptoms, cardiotoxic effects, fever, malaise, dry mouth, constipation, hemorrhagic cystitis, and other toxic side effects.
Generally speaking, however, it is rare to vomit a large amount of blood, and if it occurs, the doctor should be informed of the situation immediately, which is very dangerous and can cause hypovolemic shock within a short period of time, and may also induce severe hepatic encephalopathy if combined with severe liver disease.
It is recommended to closely monitor the patient’s condition during the pretreatment period of high-dose cyclophosphamide chemotherapy for bone marrow transplantation, and to seek immediate medical attention if there is any discomfort.