Three-year-old female baby fever 39 ℃ should be targeted treatment according to the cause of the disease, the general treatment modalities are symptomatic treatment and causative treatment. 1. symptomatic treatment: (1) drug cooling: three-year-old baby girl with a fever of 39 ℃ to first give drugs to reduce body temperature, follow the doctor’s advice to take ibuprofen suspension, acetaminophen and other drugs, fever recurrence can be through the suppository of drugs to reduce body temperature, such as acetaminophen antipyretic suppository. (2) Physical cooling: medication to lower the temperature at the same time to give physical cooling treatment, the baby should not wear too much clothing or quilt is too thick, appropriate reduction of clothing or quilt can dissipate heat to lower the temperature. With 32 ~ 34 ℃ water temperature wipe the body parts of large blood vessels, such as armpits, groin, can reduce body temperature. 2. Treatment of the cause: three-year-old baby girl with a fever of 39 ℃ is just a symptom, to go to the hospital to check the cause of the disease and then targeted treatment. Bacterial infections with antibiotic treatment such as cefixime, viral infections can be mostly self-healing, if the influenza virus caused by the application of oseltamivir and other antiviral drugs. The fever of a three-year-old baby girl is relatively serious, and it is recommended that she seek medical treatment promptly to avoid febrile convulsions. All of the above medications should be used under the guidance of a doctor, avoid self-medication.