Fetal chromosome trisomy is generally not associated with male alcohol consumption and is mainly associated with advanced maternal age. Fetal chromosome trisomy is mainly due to chromosome nondisjunction of germ cells during meiosis, but the exact cause is not known, and it is currently believed that the risk factor for trisomy is advanced gestational age. Alcohol consumption by the male partner may reduce sperm quality but does not change the structure as well as the number of chromosomes within the sperm, so fetal chromosome trisomy is not strongly associated with male alcohol consumption. Chromosome trisomy is the main abnormal karyotype of embryos miscarried in early pregnancy. Advanced age has always been the main cause of trisomy, and the incidence of trisomy increases with maternal age, so detailed prenatal diagnosis of advanced maternal age is required.