Lupus, or systemic lupus erythematosus, is an immune system disease that produces antibodies that attack its own organs and tissues. The clinical symptoms of the disease are diverse, including systemic manifestations such as fever and fatigue, as well as skin rashes, plasma membrane inflammation, arthralgia, etc. It may even involve the kidneys and other systems. 1. Systemic manifestations: most of the patients in the active stage of the disease have fever, which is common in low or moderate fever, and may be accompanied by malaise, fatigue, decreased appetite, weight loss, and so on. 2. Skin and mucous membrane manifestations: patients may have skin rashes, such as zygomatic erythema, discoidal erythema, facial and trunk rashes, etc., of which the nose bridge and zygomatic cheeks erythema is the most characteristic. 3. Plasmacytitis: more than half of the patients have multiple plasmacytomas during acute attacks, including pleural effusion and pericardial effusion. 4. Muscle and joint manifestations: arthralgia is common, mostly in finger, wrist and knee joints, accompanied by erythema is rare. Myalgia, muscle weakness, myositis, etc. may also occur. 5. Kidney manifestations: Involvement of kidneys, edema, hematuria, proteinuria, hypertension and so on. 6. Other systemic manifestations: abdominal pain, nausea, vomiting, etc. may occur when the digestive system is involved; dry cough, shortness of breath, hypoxemia, etc. may occur when the respiratory system is involved; epilepsy, headache, impaired consciousness, etc. may occur when the neurological system is involved; anemia and thrombocytopenia may occur when the blood system is involved. Early symptoms of SLE are often atypical, if the above symptoms occur, it is recommended to consult the Rheumatology and Immunology Department in a timely manner, and once the diagnosis is confirmed, standardized treatment under the guidance of the doctor as soon as possible.