Mesenteric lymphadenitis with a fever of more than 39 degrees requires anti-infective treatment along with aggressive cooling. Treatment should be carried out under the guidance of a doctor. 1. Cooling treatment: cooling measures include physical cooling and drug cooling, physical cooling can be through the cold towel to wipe the body; clinically used to lower the temperature of the drug, including acetaminophen and ibuprofen, if the effect is not good, but also with to be rehydration, intravenous lysergic acid and other treatments. 2. Anti-infection treatment: patients can be treated with intravenous antibiotics such as penicillin, ceftriaxone, levofloxacin and other drugs to inhibit infection. Due to individual differences, the drugs are not absolutely safe and effective, and need to be used in strict compliance with the doctor’s instructions, not unauthorized use of drugs. Adverse reactions to timely medical treatment, drug allergy is prohibited, cephalosporins in the use of alcohol is prohibited.