Cerebral leukoencephalopathies are a group of demyelinating disorders of the central nervous system whose specific etiology is poorly understood. It can be a secondary manifestation of neurological disorders such as infection, poisoning, degeneration, post-traumatic injury, and lack of infarction. Patients with white matter encephalopathy present with symptoms of vascular dementia, pseudobulbar palsy, and gait disturbances. As a result of extensive hemispheric white matter degeneration, demyelination can cause bilateral destruction of the corticospinal tracts and pyramidal tracts, leading to symptoms of pseudobulbar palsy. The patient may exhibit memory loss, along with cognitive decline that progresses gradually. Pseudobulbar palsy may be characterized by choking on water and coughing, progressive and uncontrollable urinary and fecal incontinence, and a small, unsteady gait when walking.