Herbal medicine can assist in the treatment of mycosis fungoides, but it requires evidence-based treatment. Mycosis fungoides is a multicenter slowly developing cutaneous lymphoma. The initial stage is pre-mycosis, also known as erythema stage, which is characterized by itching and the formation of different rashes such as papules, macules or blisters. The disease can gradually develop into plaque stage and tumor stage since the erythema stage. Chinese medicine can assist in the treatment of the disease, and clinical diagnosis and treatment are often required: Blood-heat and wind-dryness evidence can be seen in skin erythema, intense itching, bright red scratches, etc. The treatment is to cool the blood and moisten the dryness, and to dispel the wind to stop the itching (to stop the itching by removing the wind that invades the surface of the muscle). In the case of stasis-heat-fire-toxicity syndrome, nodules and lumps are seen, or the lumps are ulcerated with severe pain and dryness and bitterness in the mouth, the treatment is to invigorate blood and clear away heat, detoxify the toxin and disperse the lumps and junctions. Qi and blood deficiency syndrome is seen in prolonged illness, weakness and fatigue (mental exhaustion and physical weakness), treatment should be to replenish qi and blood. Traditional Chinese medicine can relieve the discomfort of the disease to a certain extent, and the disease may also need to be treated with local symptomatic therapy or hormone therapy in Western medicine. Specific treatments should be carried out under the guidance of a physician, do not blindly apply Chinese medicine to avoid delaying the condition.