Early diabetic neuropathy is a chronic complication of type 2 diabetes mellitus, and the disease produces is generally irreversible, so patients with type 2 diabetes mellitus should have strict glycemic control to prevent the development of complications. The treatment of diabetes includes health education, nutritional therapy, exercise therapy, condition monitoring, and drug therapy. 1. Health education: including training of diabetes prevention and treatment personnel, continuing education of medical personnel, and education of patients and their families. The purpose is to prevent the occurrence of diseases in high-risk groups of diabetes, especially patients with family genetic history. 2. Nutritional therapy: reasonable control of total calories, rational distribution of nutrients, reasonable meal distribution, control of sugar, fat, protein ratio. 3. Exercise therapy: Diabetes mellitus occurs in people with poor living habits, lack of exercise and obesity. Reasonable diet control, exercise and weight management can effectively increase insulin sensitivity and prevent the development of diabetes. 4. Condition monitoring: Accurate monitoring of fasting blood glucose, postprandial blood glucose and glycated hemoglobin changes, timely detection of disease development and take measures. 5. Medication: The most important and effective way to prevent and control diabetic neuropathy is to strictly control blood sugar and keep it stable. Methylcobalamin and prostaglandin analogs have certain effect on diabetic neuropathy. The complications of diabetes are more frequent and the prognosis is more difficult to recover, therefore, patients diagnosed with diabetes should follow the doctor’s instructions and cooperate actively to slow down the development of the disease.