Decreased glutamyl transpeptidase is most often due to liver disease, biliary tract disease and other disorders. Glutamyl transpeptidase is widely distributed in the body, with the kidneys being the most abundant, followed by the pancreas and the liver. Serum glutamyl transpeptidase is generally derived from the liver, so its value changes when there is a lesion in the liver. Acute and chronic hepatitis, intra- and extra-hepatic bile duct obstruction, cirrhosis, metastatic or primary hepatocellular carcinoma can all lead to a decrease in glutamyl transpeptidase. It is important to note that liver disease can also cause an increase in glutamyl transpeptidase, which needs to be analyzed specifically. Besides liver diseases, biliary tract diseases, acute pancreatitis, myocardial infarction and other diseases also have lowering manifestations. It is recommended to consult the regular hospital in time.