The causes and mechanisms of the disease, symptoms and clinical use of medication are different from those of Heart-Kidney Dissonance (heart fire and kidney yin deficiency, dysfunction of the heart and kidneys). The upper heat and lower cold is mostly due to the misuse of attacking and lowering of external diseases, resulting in more than one big diarrhea and damage to the fluid; the heart and kidney are not intertwined is mainly due to prolonged illness and injury to the yin, the kidney essence is insufficient, and can not constrain the heart yang, leading to the heart fire on the high side. Symptoms of upper heat and lower cold symptoms manifested in the upper part of the symptoms for the heat, such as sore throat, or even hemoptysis yellow sputum or bloody sputum; the lower part of the symptoms for the cold, such as diarrhea, cold limbs. Symptoms of Heart and Kidney Disconnection are characterized by symptoms such as heartburn, insomnia, dizziness, tinnitus, forgetfulness, lumbar and knee weakness, dry mouth and throat, and so on. According to the symptoms, we can use Half-summer Laxative Heart Soup for upper heat and lower cold syndrome, and Jiaotai Pill for heart and kidney disorders. After the discomfort should be timely medical treatment, under the guidance of the physician’s diagnosis and selection of medication, not self-medication, in order to avoid delays in the condition.