There are more chemotherapy regimens for small cell carcinoma of esophagus, but relatively speaking, EP regimen and IP regimen are more commonly used. Small cell carcinoma of esophagus is relatively rare in clinic, and its chemotherapy regimen is not fixed, which is mainly determined according to the patient’s condition, stage, etc. There are many different choices, only that the EP regimen and IP regimen are relatively more commonly used. EP program is the cisplatin drug as the basis, combined with etoposide for combination therapy; IP program is the combination of cisplatin and irinotecan for combination therapy, which can control the patient’s condition well and prolong the progression period; in addition, there are also 5-fluorouracil plus cisplatin, paclitaxel combined with fluorouracil and other programs. Specifically what program to take, according to the patient’s specific situation to decide, we recommend that the patient to the hospital in a timely manner, and actively cooperate with the treatment.