Metformin generally refers to metformin hydrochloride tablets, and cephalosporin is a general term for cephalosporin antibacterial drugs, commonly found in varieties such as ceftriaxone sodium, cefotaxime, and cefoperazone. Metformin hydrochloride and cephalosporin antibacterial drugs can be taken at the same time. Cephalosporin antimicrobials are mainly used for bacterial infections, such as respiratory, urinary tract, skin, and biliary tract infections caused by sensitive bacteria. It is contraindicated for those who are allergic to cephalosporins. Adverse reactions such as gastrointestinal discomfort and allergy are common. Metformin hydrochloride tablets are used for type 2 diabetes mellitus in which dietary control and physical exercise alone are ineffective in controlling blood glucose. It is used as monotherapy in combination with sulfonylureas or insulin. Common adverse reactions include metabolic and nutritional disorders and gastrointestinal abnormalities. The instructions for Metformin Hydrochloride Tablets do not indicate that it should not be taken concurrently with cephalosporin antibacterials. It is important to follow the doctor’s instructions when taking it to avoid adverse reactions.