High total bilirubin and indirect bilirubin may be related to physiological jaundice in newborns, or it may be caused by liver diseases such as cirrhosis and hemolytic diseases such as hemolytic anemia.
1. Physiological jaundice in newborns: Due to the short life span and destruction of red blood cells in newborns, more free bilirubin is produced, coupled with the low ability of plasma albumin to bind free bilirubin and the low ability of hepatocytes to process bilirubin, high bilirubin, which is mainly an increase in indirect bilirubin, may occur.
2. Liver diseases: such as cirrhosis, viral hepatitis and other diseases, liver cell function is impaired, the ability to take in and process free bilirubin is reduced, which may also lead to increased indirect bilirubin levels in the blood.
3. Hemolytic diseases: such as hemolytic anemia, acute blood transfusion reaction and other diseases, may lead to elevated levels of free bilirubin, which exceeds the ability of liver cells to process, and may also result in high levels of total bilirubin and indirect bilirubin.
If the values of the above two indicators are persistently elevated, you should go to the hospital in time to identify the specific cause of the disease before further treatment.