The hardening and bulging of the vessels of the indwelling needle is caused by inflammation of the vessels. This is an aseptic inflammation that presents as a painful infusion vessel, redness and swelling of the skin, increased skin temperature, and the ability to palpate a hard, painful stripe. The treatment is to avoid infusion near this vessel and to apply topical mucopolysaccharide polysulfate cream to promote the absorption of inflammation. The patient’s limbs can be kept warm and elevated, and hot compresses can be applied to activate the blood and remove blood stasis.