Bilateral mastoiditis, an inflammatory disease caused by otitis media spreading to the mastoid, can be reasonably treated by general treatment, medication, surgery and other methods. 1. General treatment: first of all, we need to keep a light diet, eat more fresh vegetables and fruits, avoid spicy and stimulating food; secondly, we need to pay attention to ear hygiene, avoid water into the ear when bathing; at the same time, we need to have a regular work and rest, pay attention to rest. 2. Medication: In the early stage of the disease, penicillin or cephalosporins can be used for treatment, such as amoxicillin, cefaclor, etc. After that, sensitive antibiotics can be used for treatment through the results of bacterial culture and drug sensitivity test. 3. Surgery: such as the commonly used tympanotomy, mainly applicable to the antibiotic treatment effect is not obvious, can be through the tympanotomy to drain the pus, clear the perforation site of the blockage, suitable for tympanic membrane is small and the drainage of pus is not smooth patients. As each patient’s condition is different, so the treatment method is also different, you need to consult the hospital in time, under the guidance of a professional doctor combined with the patient’s specific condition, choose the appropriate method for standardized medication and treatment.