Sleep to wake up in the middle of the night can not be seen in the following cases: First, see depression, one of the manifestations of depression is sleep disorders, can be difficult to fall asleep, can also be early awakening, it is difficult to fall asleep again after waking up. Second, the influence of physical diseases, such as cancer pain patients due to pain caused the patient to wake up in the middle of the night, it is difficult to fall asleep; chronic bronchitis in the acute phase, turning over at night due to phlegm displacement to stimulate the trachea, resulting in coughing causes the patient to wake up early. Third, alcohol or drug abuse, alcohol and drug addiction attacks in the middle of the night, causing physical and psychological discomfort, resulting in difficulty in falling asleep after waking up. Fourth, patients with mental disorders, due to hallucinations and hallucinations at night resulting in the inability to fall asleep after waking up. Fifth, problems with the sleep environment, such as the bedroom temperature is too low or too hot, there is noise outside, or due to jet lag, these can cause difficulty in falling asleep after waking up in the middle of the night.