HPV (Human Papilloma Virus) 39 infection is easily reversible in those with strong resistance, but not in those with poor resistance, and may even require medical intervention. Most of the HPV39 infections are transient. For young infected people with strong resistance, they can strengthen their immune system by adjusting their daily life and routine, and exercising appropriately, so as to realize self-healing. However, for middle-aged and old-aged infected people with poor resistance, it is difficult to achieve natural transformation, in addition to lifestyle modification, we also need to follow the doctor’s instructions to take immunomodulatory drugs (such as thymidine, transfer factor) to enhance the body’s immunity, to help the virus to turn negative. HPV39 is a high-risk type, long-term persistent infection can lead to cervical cancer and other negative prognosis, HPV39 infection should follow the doctor’s advice for cervical screening and related treatment.