The cause of liver discomfort should be clarified first, because some liver discomfort is caused by physiological factors, including staying up late at night, overeating, poor rest, lack of exercise, and only need to pay attention to the habits of life, the symptoms of liver discomfort can be relieved soon. If the liver discomfort is caused by other pathological factors, it is necessary to check the liver function, including tumor indicators, imaging to clarify whether the lesions in the liver are benign or malignant, or other parts of the lesions metastasized into the liver, and to clarify the cause of the disease before targeted treatment can be taken. If benign liver lesions are considered, surgical treatment is needed for intrahepatic bile duct stones, benign tumors of the liver causing changes in liver function, and extrahepatic bile duct obstruction requiring interventional or minimally invasive treatment. Internal hepatic lesions, including hepatitis, fatty liver, and liver fibrosis itself, require antiviral treatment, liver preservation, and even liver transplantation.