Closed acne can be treated with general treatment, medication and other treatments. 1. General treatment: For patients with closed acne, daily attention should be paid to keep the face clean, avoiding the use of irritating soap or cosmetics. Patients should also pay attention to adjust the diet, eat more fresh fruits and vegetables, avoid eating spicy and stimulating food. Pay attention to maintain physical and mental pleasure, sufficient sleep time. 2. Medication: Closed acne can be cleaned after the skin, follow the doctor’s instructions for external use of isotretinoin gel, 0.1% adapalene gel and other retinoic acid drugs, but also can be formulated with 2.5%, 5% concentration of benzoyl peroxide lotion to achieve astringent effect. Some patients can also apply 15%~20% azelaic acid gel to kill Propionibacterium acnes. 3. Other treatments: Some patients with closed acne may seek medical attention to improve their skin condition through fruit acid peeling and acne cleansing. Some patients may also seek treatment through photodynamic therapy, laser and other physical modalities. It is recommended that people with closed acne be treated with medication under the guidance of a physician, and should not use medication on their own.