Medial knee pain that occurs after strenuous exercise or weight-bearing work may be a result of a sports-related strain injury. This includes soft tissue damage around the knee, ligament damage, and medial meniscus damage. It is important to go to the hospital for an MRI to see the soft tissue damage around the knee for timely treatment, and to avoid further weight bearing or excessive exercise. In addition, if the medial knee pain occurs in middle-aged or elderly people, they should be alerted to the presence of osteophytes and bone spurs, and should go to the hospital for imaging and, if necessary, surgery. Pain on the inside of the knee may also be seen in patients with osteoarthritis or rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis and other diseases of the rheumatic immune system. It is important to give the appropriate treatment for each disease after a clear diagnosis.