After a digestive patient’s visit to the doctor, the doctor will often advise: “must be emotionally stable, open-minded”. This sentence may seem to be a “medical routine”, but it is very important. Bad emotions stir up the digestive tract activities, including the esophagus, stomach, small intestine, large intestine, liver, gallbladder and pancreas, including the digestive system, is an extremely sophisticated, coordinated, efficient machine, peristalsis, pressure, blood flow, temperature, digestion, absorption, secretion …… Together, they respond to a variety of changes inside and outside the body. It is not good to have an abnormality in any part or link. The esophagus is tasked only with passage, and emotions such as sadness, anger, and anxiety can narrow or even completely block the lumen of a healthy esophagus, lengthening the time it takes for food and drink to pass through. Changes in luminal pressure are also related to emotional state. Clinically, it can be seen that people complain of post-sternal congestion and unfavorable swallowing after great sorrow are not unrelated to these changes. People in hate when gastric acid secretion increases, blood flow increases, the mucosa color becomes red (congestion). At this time, the gastric mucosa is extremely brittle, even if it is a slight, small damage can become a small ulcer, some people believe that this is also for the Helicobacter pylori “down” to create the conditions. In depression, helplessness, disappointment and other emotional control, people’s gastric acid secretion will decline. The small intestine becomes more tense in response to poor mood, and a barium meal reveals a prolonged emptying time. The colon seems to be more sensitive. Colonoscopy and wave counting devices have shown that both healthy people and people with irritable bowel syndrome experience peristaltic hypermotility in response to bad moods. In sadness, depression, and disappointment, there is an increase in wave-like tension and peristalsis leading to diarrhea. In fear and frustration, the color of the colonic mucosa becomes pale and there is no contractile activity, and in anger, complaint and hostility, the mucosa becomes red and contractile activity increases. Gastrointestinal tract is known as the “second brain” The brain is a variety of physiological activities in the human body, including mental and emotional activities, including the highest command, naturally involved in external reactions. It is known that there is a family of peptides in the brain and the brain’s neural activity is closely related, such as depression, a peptide called TRH in the brain content rose. Two major discoveries were made by scientists who studied the nerves of the gastrointestinal tract in depth. First, the discovery of the enteric nervous system. The entire gastrointestinal tract is covered with more than 100 million nerve cells, from the mucous membrane layer, the muscle layer until the plasma membrane layer is densely distributed, the total number of which is second only to the brain, known as the “intestinal brain” or “second brain”. It has its own complete reflex system within the gastrointestinal wall, in layman’s terms, it can not need to go through the brain “command” order and act on its own – to regulate the gastrointestinal physiological activities, but also can be disposed of process uploaded to the “command”, affecting the “intestinal brain”, “intestinal brain” or “second brain”. Command” and influence the activities of the “Command”. The second major discovery is that there are special cells in the intestines that secrete peptides identical to those in the brain to fulfill the various commands of the enteric nervous system, so that the digestive tract’s motility, secretion, digestion, pressure, and even temperature can be regulated to adapt to various changes. The peptide hormones in the brain are identical to those in the intestines, which are far away from the brain, and thus they are given a general name – brain-gut peptides. In this way, the brain and the gastrointestinal tract not only have “land transportation” – the autonomic nervous system, but also have “waterways” – brain-gut peptides. -Brain Gut Peptide. The two are closely linked, not only can give instructions, but also uploaded, so it is called a two-way channel. From a positional point of view, the autonomic nervous center that regulates the digestive tract, the center of the endocrine system, the two sub-commands and the subcortical integration center that controls the emotions are located in the same anatomical part, so the digestive system is very susceptible to the influence of emotions and psychological factors.