High total bile acids usually manifest as problems with liver function, which usually includes problems with synthesis, excretion or uptake of liver function. Specific causes include the following: 1. Damage to liver function: this includes all types of viral hepatitis, alcoholic hepatitis or drug-related liver damage, and even cirrhosis and liver cancer, which can lead to elevated bile acids; 2. Biliary obstruction: this can also cause elevated bile acids, such as biliary stones and biliary tumors; 3. Hepatic and portal shunts: this can also lead to elevated bile acids. Of course it is more common to have physiological elevation, i.e. very mild elevation of total bile acids may not be of great significance and may be a physiological elevation caused by the different constitution of each person; 4, intestinal diseases: lead to bile acid metabolism disorder, which may also lead to elevated bile acids.