The harms of atrial septal defect usually include affecting growth and development, affecting normal life, affecting mental health, and combining other complications. 1. Affecting growth and development: huge atrial septal defects in infants lead to growth retardation and feeding difficulties, affecting normal growth and development, and impairing height and intellectual development. 2. Impact on normal life: Atrial septal defect is often accompanied by dyspnea, weakened respiration and weakened heart activity, which affects normal life. 3. Impact on mental health: Atrial septal defect is a congenital malformation of the heart. Due to the different eyes of other people around them, they have bad emotions such as fear, anxiety and uneasiness, and may show autism and unwillingness to communicate with others, which affects their mental health. 4. Combination of other complications: Atrial septal defects are more serious and are often associated with complications such as infective endocarditis and congestive heart failure. It is recommended to consult a doctor in time for relevant examination, according to the specific situation, under the guidance of the doctor, to carry out symptomatic treatment.