Atorvastatin and Rosuvastatin are commonly used lipid-lowering drugs in clinical practice. The main differences are physicochemical properties, lipid-lowering intensity, metabolic pathways, drug interactions and so on. 1. Physicochemical properties: both are synthetic statins, and their structures are different. Atorvastatin is lipophilic, while Rosuvastatin is hydrophilic. 2. Lipid-lowering intensity: For the same dose, the lipid-lowering intensity of Rosuvastatin is higher than that of Atorvastatin. 3. Metabolic pathway: Atorvastatin is mainly metabolized by the liver, while Rosuvastatin is mainly metabolized by the liver and kidney. Therefore, atorvastatin is safer than Rosuvastatin in patients with poor renal function. 4. Drug interactions: Atorvastatin has more interactions with other drugs compared to Rosuvastatin. The choice of statins should be made under the guidance of a cardiologist and should not be changed, reduced or stopped without authorization. If you feel unwell, you should seek medical advice promptly.