A toothache may signal a heart attack because the nerves controlling toothache and those affecting angina originate from the same nerve roots in the spinal cord plane. When angina occurs, nerve impulse conduction involves the surrounding nerves, the brain can not accurately distinguish whether the toothache nerve transmits impulses or the angina nerve transmits impulses, resulting in a toothache miscalculation, so toothache is a common radiating pain in angina. In addition to radiating to the tooth area, angina will also radiate to the left shoulder, left upper arm, and even the left fingers. Angina dental radiating pain is characterized by left-sided, and there is no accurate pressure point, although it feels more pain, but there is no clear pressure pain site, is more typical of angina radiating pain. If it is due to gingivitis or root inflammation and other oral diseases caused by tooth pain, most of the time there will be a clear pressure point, that is, the pain is more obvious in the lesion, which is different from angina radiating tooth pain. If the patient has frequent tooth pain, especially after exercise, and the pain site is vague, there is no accurate pressure point, it is recommended that the patient improve the electrocardiogram examination, to clarify whether there is the clinical manifestation of coronary artery disease, whether it occurs in angina pectoris radiating pain, and if necessary, can improve the coronary artery CT imaging or coronary angiography, to clarify the diagnosis of coronary artery disease. In conclusion, if there is no dental disease, the sudden appearance of unexplained toothache, and there are risk factors related to coronary heart disease, we should consider the possibility of angina pectoris or even myocardial infarction.