If the high total bile acid is related to eating, no medication is needed; it is also considered to be related to hepatitis, cirrhosis, biliary obstruction and other diseases, and patients can be treated with drugs such as N-acetylcysteine, entecavir, etc., and the drugs should be applied under the guidance of a doctor.
1. Eating: If people seek medical examination after eating, a transient increase in total bile acids may occur. Usually, this indicator returns to normal as the food is digested, and no special medication is needed.
2. Hepatitis: All types of hepatitis can cause high total bile acids. Usually, patients with drug-induced hepatitis need to stop liver damage medication and be treated with drugs such as N-acetylcysteine and polyene phosphatidylcholine. Patients with viral hepatitis can be treated with antiviral drugs such as tenofovir and telbivudine.
For autoimmune hepatitis, prednisone and azathioprine can be used for treatment, while patients with alcoholic hepatitis and steatohepatitis need to actively quit drinking and adjust their diet.
3. Cirrhosis: patients with cirrhosis may have high total bile acids, and patients with hepatitis B and C can be treated with antiviral drugs such as entecavir and daclatasvir. Ascites can be treated with furosemide, spironolactone and other drugs, and albumin can be infused if necessary.
4. Biliary obstruction: patients with biliary obstruction need to undergo surgery to relieve obstruction, choledocholithiasis for bile duct stones, pancreaticoduodenectomy or biliary stent implantation to relieve obstruction caused by tumor.
There are many other causes of high total bile acids, such as hepatocellular carcinoma, right heart failure, hepatic stasis and so on. It is recommended that the patient undergoes further detailed examination in order to clarify the disease and then follow the doctor’s instructions for treatment, so as to promote the return of total bile acid to normal.