Anti-epileptic drugs are the main way to treat patients with epilepsy, applied for a long time, and some patients need to take them for life. However, with the long-term or high doses of antiepileptic drugs, some side effects will inevitably occur, causing damage to patients’ mental psychology, nervous system, gastrointestinal function, blood system, and some allergic reactions, etc. 1. Mental psychological damage: patients will experience mental depression, drowsiness, emotional instability, depression, agitation, insomnia, forgetfulness; 2. Neurological damage: patients will experience memory loss , attention disorders, vertigo, fatigue, headache, convulsions, blurred consciousness, ataxia, etc. For the optic nerve, there are blurred vision, diplopia, nystagmus, etc.; 3. 5, allergic reactions: some anti-epileptic drugs can cause rash, drug fever, exfoliative dermatitis, maculopapular rash, etc.; 6, other: women taking anti-epileptic drugs for a long time may also lead to endocrine disorders, changes in menstrual cycle, rough skin, hair growth, and even infertility in severe cases. Pregnant women taking some antiepileptic drugs during pregnancy can lead to fetal dysplasia and malformations; the drugs have an effect on liver and kidney function, with elevated transaminases; endocrine disorders such as reduced insulin secretion; and some drugs can cause rickets in children when taken for a long time. Improper selection of epilepsy drugs may lead to aggravation of seizures. Patients should first take their medication strictly at regular intervals and quantitatively under the guidance of their doctors, and should not stop medication on their own. Secondly, check the cause of epilepsy and use different treatment methods according to different causes. Finally, during the period of taking medication, pay attention to a diet that is nutritious and avoid spicy and stimulating foods.