Post-cholecystectomy syndrome is a condition in which the original symptoms do not disappear after cholecystectomy or new symptoms occur on top of that. Common symptoms include abdominal pain, recurrent pancreatitis, jaundice, dilated common bile duct, liver dysfunction, etc. It is generally believed that about 25%-30% of gallbladder resection can have transient symptoms that can disappear quickly, and about 2%-8% can require active treatment because the symptoms persist. The etiology of post-cholecystectomy syndrome mainly includes: 1. Bile duct stones are the most common cause of post-cholecystectomy syndrome. The literature reports an incidence of 5% to 75%, and can even be as high as 87.8%. It can be divided into residual stones and recurrent stones. Residual stones are mostly due to careless intraoperative exploration or unskilled technique. Or intraoperative exploration reveals intrahepatic bile duct stones, which are difficult to remove due to technical difficulties. Or due to critical condition, detailed exploration or stone extraction is not allowed. Recurrent stones are stones that have been removed at the time of surgery and occur again later. Some people believe that those who have developed symptoms for more than two years can be designated as recurrent stones. 2.Stenosis after bile duct injury: bile extravasation after injury, biliary peritonitis occurs, even if it heals, it will continue to be fibrotic stenosis, poor bile drainage, and recurrent biliary duct infection. Stenosis, infection and recurrence of stones are mutually causal, forming a vicious circle. 3, the gallbladder duct remains too long: after cholecystectomy, the gallbladder duct remains more than 25px is residual too long. Generally, it does not cause symptoms, but if there are stones in the cystic duct or obstruction in the lower end of the cystic duct, poor bile drainage, increased pressure in the lumen, dilatation of the residual cystic duct and secondary infection, forming a small gallbladder with inflammation. The main symptoms are abdominal pain, fever, and in some cases, jaundice. Other symptoms include indigestion, anorexia, abdominal distension, nausea and vomiting. 4.Post-biliary dysfunction: It is common in young women and can be induced by mental factors or endocrine dysfunction. It is manifested as paroxysmal right upper abdominal pain with abdominal distension, excessive sweating, rapid heart rate, etc.. However, there are no symptoms of infection and no positive findings on X-ray or ultrasound. 5.Symptoms existed before cholecystectomy: The symptoms were masked by the gallbladder lesion. After cholecystectomy, the symptoms of gallbladder disease disappeared and the symptoms of extra-biliary diseases showed up.