The pre-menopausal manifestations are called perimenopausal syndrome, and common symptoms include menstrual disorders, abnormal vasoconstriction, and neurological disorders. 1. Menstrual disorders: mainly manifested by irregular menstrual cycles, i.e., prolonged or shortened, with an increase in the amount of menstrual blood followed by a gradual decrease until it stops. 2. Abnormal vasoconstriction: The common symptom is hot flashes, which appear repeatedly and transiently on the chest, neck and face, and are accompanied by sweating, fear of cold, palpitation, headache and other symptoms. 3. Neurological disorders: clinically, it is mainly manifested as a large range of mood fluctuations, often with symptoms such as agitation, irritability, suspiciousness, anxiety, depression, memory loss, poor concentration, insomnia and so on. Perimenopausal syndrome is the transition from fertility to menopause, which is mainly related to endocrine disorders, and the symptoms can disappear on their own when they enter menopause. To summarize, women’s pre-menopausal manifestations are quite diversified, with obvious individual differences, and it is necessary to strengthen daily life management during this stage to help relieve discomfort.