Taking a timosartan capsule in the morning the next day the blood pressure of the systolic blood pressure threw 150mmHg or more can be replaced with other drugs or a combination of other drugs for treatment. 1. Replacement of drugs: If the patient is a long-term oral timosartan capsules, blood pressure still can not be controlled below a safe level can be replaced with other drugs, such as nifedipine extended-release tablets, enalapril maleate and so on. If for the first time to use the drug, it is recommended to continue to take the drug, do not change the drug frequently, when to achieve a smooth blood concentration still can not control the person to consider changing the drug treatment. 2. Combination of drugs: for long-term blood pressure control is not good, you can consider the combination of drug therapy, or the use of composite drugs, such as diphenhydramine combined with sartans, sartans combined with diuretics and so on. If you really need to combine drugs, you need to do it under the guidance of a physician to avoid drug interactions or adverse reactions such as hypotension. It is recommended that patients seek medical attention in a timely manner, under the guidance of a physician to carry out the next step in the treatment program, and closely monitor the changes in blood pressure.