Gastroesophageal Reflux Disease (GERD) in Chinese medicine can be categorized as choking, noisy (stomach feeling similar to hunger, emptiness with burning), regurgitation and so on. Wu Bei San is effective in relieving symptoms and treating GERD that is characterized by liver-stomach disharmony, but whether it can be cured varies from person to person and from condition to condition. Wu Bei San is a kind of proprietary Chinese medicine, which is composed of cuttlebone, Chen Pi oil and so on. This proprietary Chinese medicine has the effect of suppressing acidity and pain (suppressing stomach acid to relieve pain), and astringent and hemostatic (treating bleeding conditions with medicines that have astringent effect). It is mainly used for treating gastric pain, acidity and noisiness caused by disharmony between the liver and stomach; it also has therapeutic effect on peptic ulcer with the above symptoms. The adverse reactions and contraindications of this product are not yet clear. Drugs need to pay attention to, avoid eating spicy food, spleen and stomach yin deficiency avoid use, pregnant women should be cautious. From the drug description of this product, Wu Bei San for liver and stomach disharmony caused by gastroesophageal reflux disease (choking, noisy, regurgitation) has a certain degree of symptomatic relief and therapeutic effect, other evidence should be standardized under the guidance of a traditional Chinese medicine practitioner treatment. Chinese medicines or proprietary Chinese medicines need to be used under the guidance of a Chinese doctor to identify the evidence, and individuals should not use them blindly to avoid adverse consequences.