Whether lipoprotein a as high as 427mg / L is serious or not should be assessed on the patient’s risk, such as belonging to the intermediate and high risk patients, the condition is serious. The normal value of lipoprotein a is <300mg/L, lipoprotein a reaches 427mg/L to be considered significantly elevated, able to increase the risk of atherosclerosis, but the specific severity of the condition depends on whether the patient combines multiple risk factors, such as smoking, early onset family history of cardiovascular disease, hypertension, diabetes, etc., combined with a variety of risk factors of ten years the risk will be significantly higher, and the patient's condition severity will be significantly increased. Patients with elevated lipoprotein a levels alone, in the absence of significant risk factors, have a lower severity of disease. Patients with elevated lipoprotein a should be evaluated for risk under the supervision of a physician and given targeted therapy if necessary.