Focal proliferative lupus nephritis with high creatinine is usually caused by complications of lupus nephritis or medication factors, and the way to make it return to the normal value usually includes treating the primary disease and stopping medication. 1. Treatment for primary disease: lupus nephritis will cause creatinine increase and lead to impaired renal function, immunoglobulin test, antinuclear antibody test, renal hemogram test and urine protein test need to be perfected to assess the condition, and the treatment methods include glucocorticosteroid therapy commonly used drugs, such as methylprednisolone, immunotherapy commonly used drugs, such as cyclophosphamide and cyclosporine, plasma exchange therapy, and so on. 2. Discontinuation of medication: The application of some anti-rheumatic drugs may also cause creatinine elevation, resulting in drug-induced kidney injury. Therefore, it is necessary to comprehensively analyze whether there is nephrotoxicity of the drugs taken, such as cyclosporine, etc., and then stop the drugs and receive renal therapy, such as nephronin and other drugs. Focal proliferative lupus nephritis patients with high creatinine, it is recommended to consult a doctor in a timely manner, under the guidance of the physician active treatment, do not self-medication.