For the patient’s physical examination, if the check of hepatitis B three systems, suggesting that all results are negative, firstly, the patient is mostly considered not infected with chronic viral hepatitis B. Secondly, the patient has no self-immune protection mechanism, that is, the patient has no hepatitis B surface antibody, no immunity to hepatitis B virus, the patient is prone to the possibility of chronic viral hepatitis B infection. It is recommended that the patient actively consider vaccination for immune protection, the patient should consider the second injection of hepatitis B vaccine one month after the first injection, and then the third injection of hepatitis B vaccine in six months, after the hepatitis B vaccination is completed, the patient should have a blood test to see if the patient is positive for hepatitis B surface antibody and if the titer is above ten. If the titer is positive and above ten, the patient has established a self-immune protection mechanism and is immune to chronic viral hepatitis B and will not be infected with the hepatitis B virus. Patients should also pay attention to more rest, not to stay up late, not to work hard, and not to drink alcohol. In addition, for patients who have not formed hepatitis B surface antibodies after hepatitis B vaccination, they should also check for other diseases to see if there is a possibility of primary disease of the immune system.