Positive proteinuria has the potential to progress to uremia, but whether or not it will progress to uremia needs to be determined by a combination of the cause of the disease, the condition and the effectiveness of treatment. If it is physiological proteinuria, or the condition is mild and the treatment effect is good, it may not progress to uremia; if it is pathologic proteinuria, and the condition is severe and the treatment effect is poor, with the development of the condition, it may progress to uremia. Physiological proteinuria may be related to strenuous exercise, fever, mental stress, change of body position, drug effects, etc., usually after their own habits or mentality adjustment can be improved, without special treatment, usually does not progress to uremia. Pathological proteinuria can be caused by a number of disease factors, such as primary glomerular disease, diabetic nephropathy, tubulointerstitial disease, etc. If the condition is mild and the treatment effect is good, it may not progress to uremia; if the condition is more serious and the treatment effect is not good, with the development of the condition, it may progress to uremia. Proteinuria positive may also have other causes, it is recommended that patients go to the regular hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to target treatment or treatment.