Small granules at the glans coronal groove, possible diseases and treatment are as follows: First, penile pearl rash, which is the most common one, most often seen in patients with prolonged prepuce or prepuce, due to prolonged local chronic stimulation, as well as the foreskin completely wrapped the glans chronic hypoxia and other formations. Generally there is no symptom painless, there is no self-conscious symptom, and there is no pain feeling when touched by hand, without any treatment. However, if the patient has a psychological barrier or psychological burden, it can be completely cured by laser electrocautery. After electrocauterization, it is recommended to perform circumcision to avoid its recurrence. Second, warts, it is common in the glans coronal groove urethral orifice, and even on the foreskin with cabbage pattern granulation structure, usually the surface of the dirty with a certain bad smell, and sometimes can bleed when touched with the hand. It is a sexually transmitted disease, can have symptoms of peripheral dissemination, and can be further spread to sexual partners, such cases are recommended to seek medical attention. If warts are diagnosed, localized electrocautery can be used, and interferon can be used as an antiviral treatment.