Big toe pain may be caused by physiological reasons such as inappropriate shoes and long-term strain, or it may be caused by pathological factors such as gout and bunion. 1. Physiological reasons: most people’s big toe is relatively wide, if the choice of shoes is inappropriate, it will lead to long-term impact between the big toe and shoes, resulting in big toe pain; in addition, people who often exercise and walk for a long time, due to the long-term strain on the big toe, it may induce aseptic inflammation, resulting in pain symptoms. 2. Pathological factors: When gout occurs due to hyperuricemia, it can lead to deposition of uric acid in the joints of the big toe, which affects the normal movement of the joints and leads to pain, and in severe cases, gouty stones may even occur; when the first metatarsophalangeal joint is tilted to the lateral side to appear bunion due to various reasons, big toe pain may also occur. There may be other reasons for big toe pain, so it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.