The big toe grows like a blister and a little swollen and painful can be treated by daily care, drugs, physical and other methods, but due to the cause of big toe grows like a blister and a little swollen and painful causes are more, such as: trauma, gingivitis, etc., the specific treatment methods are as follows: 1. Trauma: attention should be paid to personal safety, wearing comfortable shoes and socks, avoiding local extrusion, can be localized hot compresses, promote blood circulation, conducive to the recovery of the condition. 2. Nail groin inflammation: you can use iodophor, aluminum acetate solution for cleaning, apply mupirocin ointment, fusidic acid cream and other drugs, but also abscess drainage, nail extraction, surgical excision and other methods of treatment. Due to the cause of the big toe like blisters and a little swollen and painful causes more, the specific treatment should also be based on the cause of the disease as well as under the guidance of a professional physician, to avoid adverse reactions.