Azithromycin is a macrolide class of antibiotics, it has a more important side effect, that is, it can irritate the gastrointestinal tract, patients may have abdominal pain, nausea, vomiting, and even diarrhea after taking azithromycin. Therefore, if you are taking azithromycin, it is advisable not to take azithromycin on an empty stomach, and taking it after a meal can reduce the stimulation of the gastrointestinal tract. And if you eat azithromycin indeed gastrointestinal reaction is relatively large, you can add some mucosal protective agents, or PPI preparations, such as omeprazole and other joint use. If these treatments still have more obvious gastrointestinal irritation, the patient is advised to stop taking azithromycin, and can switch to other antibiotics for anti-inflammatory and symptomatic treatment.