Flesh pain in the toenail may be caused by diseases such as onychomycosis, ingrown nails and trauma, which can be treated by medication and surgery. 1. Inguinitis: it may be due to the skin damage caused by cutting nails, which leads to bacterial invasion of the nail groove, and over time bacterial infection will occur, resulting in redness, swelling and pain in the nail groove area, and in severe cases, there will be pus secretion. Patients with inguinitis can be treated with topical mupirocin ointment and other treatments, and after abscess formation can be surgically incised and drained, with regular medication changes. If the recurrence of chronic inguinitis, can be treated by surgical excision of the affected side of the toenail. 2. ingrown toenail: the toenail of the big toe of the foot grows into the flesh, causing inflammation and pain, you can choose amoxicillin, cefuroxime and other drugs to treat. If it is a serious ingrown toenail, it can be treated by removing or repairing some or all of the nail pieces. 3. Trauma: Trauma caused by the flesh pain of the toenail, if the wound is broken, can be used externally with povidone-iodine and other disinfectants to prevent infection, and take ibuprofen, diclofenac sodium and other painkillers to relieve pain treatment. Patients with painful toenails are advised to go to the hospital in a timely manner, to clarify the cause of the disease and then standardize the treatment according to the doctor’s instructions.