Tremor of the feet is one of the features of Parkinson’s disease. Parkinson’s disease, also known as idiopathic Parkinson’s disease (PD), or Parkinson’s disease, also known as paralysis agitans (shaking palsy), is a common neurodegenerative disease of the middle-aged and elderly, and is the most common extrapyramidal disease of the middle-aged and elderly. The prevalence is 1000 per 100,000 people over 65 years of age and increases with age, slightly more in men than in women. The main clinical features of the disease: resting tremor, slowed and reduced movements, increased muscle tone, and postural instability are the main characteristics. Routine tests for foot tremor due to Parkinson’s disease: 1. Molecular biology test: This test uses high performance liquid chromatography, by which the reduced level of hva in the cerebrospinal fluid and urine of patients can be effectively detected. Genetic testing uses dna blotting techniques, pcr, dna sequence analysis, etc. Gene mutations may be found in a few familial pd patients. 2, blood cerebrospinal fluid examination: can quickly check whether the patient’s dopamine level is reduced, its metabolite hypericin concentration is reduced. 5-hydroxytryptamine metabolite and -hydroxyindoleacetic acid content is reduced; dopamine beta hydroxylase is reduced; cerebrospinal fluid growth inhibitor is significantly reduced and -aminobutyric acid level is reduced, etc. 3, routine laboratory tests: Routine laboratory tests are a must for Parkinson’s patients. Generally are in the normal range, individual may have hyperlipidemia, diabetes, abnormal electrocardiogram and other changes. 4, brain ct, mri examination: check Parkinson’s disease of this test is generally no characteristic seen. Elderly patients may have varying degrees of brain atrophy, ventricular enlargement, some patients with cerebral lacunar infarct foci, individual appearing basal ganglia calcification. Recently, some scholars have demonstrated that white matter high signal is seen in the t1-weighted image of pd patients in mri, and it appears in the anterior part of the hemiventricular center and the white matter around the anterior horn of the lateral ventricle. 5, functional imaging: functional imaging is the use of pet or spect and specific radionuclide detection to obtain the results of the examination. It can detect early hypersensitivity (compensatory phase) and late hyposensitivity (decompensatory phase) of d2 dopamine receptor activity and reduced dopamine synthesis in early diagnosis, differential diagnosis and monitoring of disease progression. However, it is expensive and has not been widely used in clinical practice.
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