Kawasaki disease, also known as mucocutaneous lymph node syndrome, occurs in approximately 15 to 20 percent of untreated children with coronary artery damage and is referred to as an epidemic or mini-epidemic. The onset of the disease is most common in infants and young children and is characterized by fever, with temperatures as high as 39-40 degrees for two weeks or longer, and ineffective treatment with antibiotics. Patients may develop bulbar conjunctival congestion, dry and cracked lips, oral congestion, protruding tongue papillae with a prune tongue, polymorphic erythema of the skin, and enlarged lymph nodes.